ENGERIX-B
Hepatitis B surface antigen (recombinant)
10 mcg / 0.5 mL · suspension · intramuscular · birth to 19 years
Hepatitis B
Hepatitis B
ENGERIX-B · RECOMBIVAX HB
Three doses over six months; two for some adolescents. Every product below is a Health Canada authorized vaccine; every schedule comes from the Canadian Immunization Guide.
- Products
- 6
- Dose schedules
- 4
- Guidance checked
- 2026-09-27
Authorized products
Brand names and DINs (Drug Identification Numbers) as Health Canada's Drug Product Database lists them. The product monograph is the manufacturer's full prescribing information approved by Health Canada.
ENGERIX-B
Hepatitis B surface antigen (recombinant)
20 mcg / 1 mL · suspension · intramuscular · 20 years and older; 11 to 15 two-dose; dialysis as a double dose
RECOMBIVAX HB
Hepatitis B surface antigen (recombinant)
5 mcg / 0.5 mL · solution · intramuscular · birth to 19 years
RECOMBIVAX HB
Hepatitis B surface antigen (recombinant)
10 mcg / 1 mL · suspension · intramuscular · 20 years and older; 11 to 15 two-dose
RECOMBIVAX HB
Hepatitis B surface antigen (recombinant)
10 mcg / 1 mL · solution · intramuscular · 20 years and older; 11 to 15 two-dose
RECOMBIVAX HB
Hepatitis B surface antigen (recombinant), dialysis formulation
40 mcg / 1 mL · suspension · intramuscular · dialysis and some immunocompromised adults 20 and older
Before and after vaccination
- Bring your immunization record so earlier doses can be checked.
- Discuss a serious reaction to a previous vaccine, relevant health conditions, medicines and allergies before receiving a dose.
- After vaccination, stay where you can be observed for at least 15 minutes and report feeling faint or signs of an allergic reaction right away.
- Keep the vaccine name, date and dose in your immunization record.
Based on the Canadian Immunization Guide's administration practices and acute reactions guidance.
Pregnancy & breastfeeding
Pregnancy
Recommended for people without immunity who are at high risk of exposure.
Breastfeeding
Use if indicated.
Source: Immunization in pregnancy and breastfeeding: Canadian Immunization Guide — Chapter updated August 2026. Live vaccines are generally contraindicated in pregnancy; routinely recommended vaccines can be given while breastfeeding unless the chapter says otherwise.
How many doses
The schedules the Canadian Immunization Guide describes for this vaccine. Which one applies depends on age, health and product — use the dose planner to see the dates for your situation.
Hepatitis B — standard three-dose series
3 dosesStandard hepatitis B series at months 0, 1 and 6.
Minimum intervals: 4 weeks between doses 1 and 2, 2 months between doses 2 and 3, and 4 months between doses 1 and 3. The age-appropriate product and dose are chosen by your healthcare professional; blood testing after the series is needed for some people.
ProductsENGERIX-BRECOMBIVAX HB
Hepatitis B — adolescents 11 to 15 years, two doses (adult dose)
2 dosesTwo adult-strength doses at months 0 and 4 to 6, for adolescents 11 to less than 16 years.
For 11 to less than 16 years of age, the standard adult dose (RECOMBIVAX HB 10 mcg, or ENGERIX-B 20 mcg) may be given as two doses, the second 4 to 6 months after the first, when a three-dose series is unlikely to be completed.
ProductsRECOMBIVAX HBENGERIX-B
Hepatitis B (ENGERIX-B, double dose) — dialysis or weakened immune system, four doses
4 dosesTwo 20 mcg injections at each of months 0, 1, 2 and 6.
For adults 20 years and older on dialysis, with chronic renal failure or with some immunocompromising conditions, using ENGERIX-B at double the usual dose (40 mcg) at months 0, 1, 2 and 6. Blood testing after the series is required.
ProductsENGERIX-B
Hepatitis B (RECOMBIVAX HB 40 mcg dialysis formulation) — three doses
3 dosesThe 40 mcg dialysis formulation at months 0, 1 and 6.
For adults 20 years and older on dialysis, with chronic renal failure or with some immunocompromising conditions: RECOMBIVAX HB dialysis formulation (40 mcg) at months 0, 1 and 6. Blood testing after the series is required.
ProductsRECOMBIVAX HB
References and product information
- Hepatitis B vaccines: Canadian Immunization Guide — Chapter revised March 2017 · erratum May 2022
- Vaccine administration practices: Canadian Immunization Guide
- Anaphylaxis and other acute reactions: Canadian Immunization Guide
- Health Canada Drug Product Database — product records and monographs
- Pharmasist vaccine reference: ENGERIX-B
Clinical rules reviewed on 2026-09-27. General information from public Canadian guidance; a personal assessment is needed for treatment decisions. Care365 does not decide whether a vaccine is publicly funded in Ontario.