Doxylamine-Pyridoxine

• This medicine treats nausea and vomiting during pregnancy, sometimes called morning sickness.
• It combines an antihistamine with vitamin B6 and can be used at any point during pregnancy.

• Swallow the tablets whole with a glass of water. Do not crush or split them, since they are made to release slowly.
• You can take this medicine with or without food. Taking it with food may make it work more slowly, so it is usually taken without regard to meals.
• Take this medicine on a regular schedule, not just when you feel sick, since it works best when taken ahead of your usual symptoms.
• A common pattern is a larger dose at bedtime to prevent morning sickness, plus smaller doses during the day if needed.
• Take this medicine exactly as your healthcare professional tells you. The amount and timing will be on your prescription label.

If you miss a dose

• If you miss a dose, take it as soon as you remember.
• If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not take two doses at once.

• This medicine is meant to be used during pregnancy and can be used in any trimester.
• Extensive research has not shown an increased risk of birth defects with this medicine.
• This medicine is not recommended while breastfeeding, since it can pass into breast milk and affect your baby.

• Tell your healthcare professional if you have asthma, glaucoma, a stomach ulcer, or any blockage of your stomach or bladder.
• Tell your healthcare professional about all medicines you take, especially any medicine for depression called a monoamine oxidase inhibitor (MAOI), since this medicine cannot be used together with those.
• Tell your healthcare professional if you are breastfeeding, since this medicine is not recommended while nursing.

Important warnings

• This medicine can make you very sleepy. Do not drive or use machinery until you know how it affects you.
• Do not drink alcohol while taking this medicine, as it can add to the sleepiness and other effects.
• Taking too much of this medicine can be dangerous, especially for children. Keep it locked away and out of sight.
• If you need to stop this medicine after taking it for a while, lower the dose gradually with your doctor's guidance rather than stopping all at once.

• Sleepiness.
• Dizziness.
• Tiredness.
• Stomach upset or heartburn.
• Headache.
• Dry mouth.
• Vivid dreams or trouble sleeping.
• Mood changes, such as feeling more anxious or irritable.

When to get emergency help

• Get help right away if you have a seizure.
• Get help right away if you have a fast or irregular heartbeat.
• Get help right away if you have signs of a severe allergic reaction, such as swelling of the face or throat, hives, or trouble breathing.
• Get help right away if you or someone else cannot be woken up after taking this medicine.

When to contact a healthcare professional

• Contact your doctor if you have trouble urinating.
• Contact your doctor if you have blurred vision or eyes that are very sensitive to light.
• Contact your doctor if your nausea and vomiting do not improve, or if you cannot keep fluids down.
• Contact your doctor if you notice unusual confusion or restlessness.

• You can take this medicine with or without food.
• Avoid alcohol while taking this medicine.
• Do not take this medicine with sleep aids, sedatives, or other medicines that make you drowsy, unless your doctor tells you to.
• Tell the Care365 care team about all medicines and supplements you take, since some can interact with this medicine.

• Store this medicine at room temperature, away from light.
• Keep this medicine out of the reach and sight of children.
• Ask the Care365 care team how to safely dispose of any unused or expired medicine.