Doxycycline (Modified-Release, Low-Dose)

• This medicine is a once-daily capsule that treats the red bumps and pimples of rosacea. It uses a very low dose of the antibiotic doxycycline that works by calming inflammation rather than fighting infection.

• Take one capsule once a day in the morning, on an empty stomach -- at least 1 hour before or 2 hours after eating.
• Swallow it with a full glass of water, and do not lie down right after taking it.
• Do not take antacids, or calcium, iron, or magnesium supplements, within 2 to 3 hours of this medicine -- they reduce how well it works.

If you miss a dose

• Skip the missed dose and take your next dose at the regular time. Do not take two doses at once.

• Do not take this medicine if you are pregnant, might become pregnant, or are breastfeeding.

• Tell your healthcare professional if you are pregnant, breastfeeding, or could become pregnant.
• Tell them if you have myasthenia gravis, liver problems, or a history of stomach surgery (such as gastric bypass).
• Tell them about all other medicines you take, especially antacids, iron or calcium supplements, blood thinners, diabetes medicines, or isotretinoin.

Important warnings

• This medicine can make your skin much more sensitive to sunburn -- use sunscreen and limit sun and tanning-bed exposure.
• Severe diarrhea during or after treatment could be a sign of a serious bowel infection -- contact your doctor if this happens, even after you've finished the capsules.
• Rarely, this medicine can cause increased pressure in the head, with headache and blurred vision -- contact your doctor right away if you notice vision changes.
• This medicine must not be used during pregnancy (it can permanently discolour a baby's teeth and affect bone growth) or while breastfeeding.
• Do not use this medicine in children under 8 years old.

• Diarrhea, upset stomach, or stomach pain
• Headache
• Nausea
• Vaginal yeast infection or oral thrush

When to get emergency help

• Severe or bloody diarrhea
• Sudden vision changes or a severe headache
• Signs of a serious allergic reaction: swelling of the face or throat, difficulty breathing, widespread rash

When to contact a healthcare professional

• If diarrhea is severe or does not go away.
• If you notice joint pain, fever, or a new rash.
• If you develop unusual bruising, yellowing of the skin or eyes, or dark urine.

• Avoid taking this medicine with milk, dairy products, or calcium-fortified juice -- wait at least 2 to 3 hours.
• Avoid combining with isotretinoin or other oral acne/rosacea retinoids.
• Tell the Care365 care team if you take blood thinners, diabetes medicines, or hormonal birth control, since this medicine can affect how well they work.

• Store at room temperature (15°C to 25°C) in the original package, away from light.
• Keep out of the reach of children.