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Medication guide

Amoxicillin/Clavulanate

Treats selected susceptible bacterial infections.

Check the name, strength and form on your own prescription or package.

Brand
Clavulin
Form
Oral antibiotic combination
Guidance checked
2026-09-08

About this medication

  • This medicine is an antibiotic used to treat bacterial infections, including sinus infections, ear infections, chest infections, skin infections, and urinary tract infections.
  • It combines two ingredients: one kills bacteria, and the other helps stop certain bacteria from destroying the first ingredient before it can work.

Treats selected susceptible bacterial infections.

How to use it

  • If you take the tablets: swallow them whole at the start of a meal to help prevent stomach upset.
  • If you use the liquid suspension: shake the bottle well before every dose, and use the measuring device given to you by the Care365 care team. Take it at the start of a meal.
  • Take this medicine exactly as your healthcare professional tells you. The amount and how often you take it will be on your prescription label.
  • Finish all of the medicine, even if you feel better before it is gone, unless your healthcare professional tells you to stop.
  • Try to take your doses evenly spaced through the day.

If you miss a dose

  • Take the missed dose as soon as you remember.
  • If it is almost time for your next dose, skip the missed dose and go back to your regular schedule.
  • Do not take two doses at once.

Use the exact prescribed strength: different amoxicillin-to-clavulanate ratios are not interchangeable. Kidney impairment may require adjustment.

Pregnancy and breastfeeding

  • Tell your healthcare professional if you are pregnant, since this medicine is only used in pregnancy when clearly needed.
  • This medicine can pass into breast milk. Talk to your healthcare professional before breastfeeding while taking it.

Discuss pregnancy and breastfeeding; watch for infant diarrhoea or thrush if advised.

Before you use it

  • Tell your healthcare professional if you are allergic to penicillin or cephalosporin antibiotics.
  • Tell your healthcare professional if you have ever had liver problems, especially jaundice, after taking this medicine or a similar antibiotic.
  • Tell your healthcare professional if you have mononucleosis (mono), since this medicine is more likely to cause a rash in that case.
  • Tell your healthcare professional about all other medicines you take, especially blood thinners and hormonal birth control.
  • Tell your healthcare professional if you are pregnant or breastfeeding.

Important warnings

  • This medicine can cause a serious allergic reaction, including swelling of the face or throat and trouble breathing. Get emergency help right away if this happens.
  • This medicine can cause severe diarrhea caused by an infection in the bowel. This can happen during treatment or even weeks after you finish. Tell your healthcare professional if you have watery or bloody diarrhea.
  • This medicine can rarely cause serious liver problems. Tell your healthcare professional if you notice yellowing of your skin or eyes, dark urine, or unusual tiredness.
  • This medicine can cause a serious skin reaction with blistering or peeling skin. Stop taking this medicine and get medical help right away if this happens.

Avoid serious penicillin allergy and previous liver injury caused by this combination.

Possible side effects

  • Diarrhea
  • Nausea or vomiting
  • Yeast infection of the mouth or vagina
  • Stomach cramps, gas, or indigestion
  • Loss of appetite
  • Headache
  • Dizziness

Diarrhoea, nausea and abdominal discomfort.

When to get help

When to get emergency help

  • Swelling of your face, lips, tongue, or throat
  • Trouble breathing
  • Severe or blistering skin rash
  • Severe watery or bloody diarrhea

When to contact a healthcare professional

  • Yellowing of your skin or eyes, or dark urine
  • A rash that is not severe but is bothering you
  • Diarrhea that does not go away, even after you finish this medicine
  • Unusual bruising or bleeding
  • Black, hairy-looking tongue, or tooth staining in children, which is harmless and goes away

Seek care for jaundice, severe diarrhoea, breathing difficulty or blistering rash.

Other medicines and products

  • This medicine can make hormonal birth control pills, patches, or rings less effective. Use an additional method of birth control, such as condoms, while taking this medicine.
  • Tell the Care365 care team if you take blood thinners like warfarin, since this medicine can change how they work.
  • Take this medicine at the start of a meal to help it work well and reduce stomach upset.

Review warfarin, methotrexate and other medicines.

Missed doses, storage and accidental exposure

  • If you have tablets, store them in a dry place at room temperature.
  • If you have the liquid suspension, store the unmixed powder at room temperature. Once the Care365 care team mixes it, keep it in the refrigerator and throw away any unused portion after the date the Care365 care team gives you.
  • Keep this medicine out of reach of children.

Follow your own product’s missed-dose instructions. If you are unsure, ask the Care365 clinical team before taking an extra dose. Contraceptives, injections and modified-release medicines may need a specific plan.

Keep the original packaging and follow its storage, expiry and disposal instructions. Keep medicines away from children and pets. Ask about refrigeration, after-opening limits and safe sharps disposal when relevant.

For suspected overdose or accidental swallowing, contact poison control or urgent medical care promptly. Call emergency services for breathing difficulty, collapse or a seizure.

Key points to remember

  • Finish the full course of this medicine, even if you feel better.
  • Use a backup method of birth control if you take hormonal contraceptives.
  • Tell your healthcare professional about any diarrhea that develops during or after treatment.

These practical points come from the Pharmasist patient handout for the same product monograph cited by this guide.

References and product information

Sources checked .

Sources checked 2026-09-08. Safety sections are highlights; consult the full product information for complete warnings and instructions.

Check the Canadian Drug Product Database by product name or DIN for current product information.

This is a plain-language guide, not the complete monograph. Match the name, strength and form on your package before using product-specific directions.

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